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aggregation activities antiplatelet

aggregation activities antiplatelet,Antiplatelet aggregation activity of diterpene . - Science DirectAug 2, 2002 . Primary studies of the structure–activity relationships for inhibition of PAF-induced aggregation showed that the oxygen substitution at the C-15 position and the presence of an oxazolidine ring in spiramine alkaloids were essential to their antiplatelet aggregation effects. These results suggest that the.aggregation activities antiplatelet,Design, Synthesis, and In Vitro Antiplatelet Aggregation Activities of .Mar 15, 2015 . Abstract. In order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. The in vitro antiplatelet aggregation activities of these compounds were assessed by turbidimetric test. The results showed that the target compound 7f.

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IN VITRO ANTI-PLATELET AGGREGATION ACTIVITY OF A .Jan 19, 2016 . Full-text (PDF) | Cardioprotection includes all mechanisms and means that contribute to the protection of the heart by reducing or even preventing myocardial damage. Antiplatelet drugs reduce the incidence of cardiovascular events by about 20-25% in people with established cardiovascular diseases.aggregation activities antiplatelet,Antiplatelet aggregation activity of diterpene alkaloids . - Europe PMCSix diterpene alkaloids with an atisine-type C(20)-skeleton isolated from the Chinese herbal medicines Spiraea japonica var. acuta and S. japonica var. ovalifolia, as well as eight derivatives of spiramine C and spiradine F were evaluated for the ability to inhibit aggregation of rabbit platelets induced by arachidonic acid,.

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aggregation activities antiplatelet,

Antiplatelet activities of hyperoside in vitro and in vivo: Animal Cells .

Jun 19, 2014 . However, antiplatelet properties of hyperoside have not been studied. In this study, the antiplatelet activities of hyperoside were measured by thrombin- or collagen-induced platelet aggregation in vitro, adenosine diphosphate-induced platelet aggregation in vivo, and the thrombus formation in vivo.

Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2 .

A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma using light transmission aggregometry. Among the tested derivatives.

Antiplatelet Aggregation Activity of Walnut Hull . - Science Direct

Identically, N-acetylcysteine inhibited the increase of reactive oxygen species level induced by thrombin in platelets, and supported a link between cellular redox status and caspase activation in activated platelets. Presumably, the antiplatelet activity of wal hull extract is related to its polyphenolic compounds and their.

Design, Synthesis, and In Vitro Antiplatelet Aggregation Activities of .

Mar 15, 2015 . Abstract. In order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. The in vitro antiplatelet aggregation activities of these compounds were assessed by turbidimetric test. The results showed that the target compound 7f.

Synthesis and in-vitro Anti-platelet aggregation activity . - CiteSeerX

Oct 3, 2013 . Plan: To synthesize some novel 2-amino thiophenes with various substitutions at 2-amino position for anti-platelet aggregation activity. Preface: Various substituted and condensed thiophenes are reported to possess a wide variety of biological and pharmacological activities such as antibacterial, antifungal.

Isolation, Synthesis, and Antiplatelet Aggregation Activity of .

Resveratrol 3-O-β-d-glucopyranoside (1) has been isolated from the seeds of Erythrophleum lasianthum (Caesalpinioidae, Leguminosae), a South African plant used in traditional medicine, and has shown antiplatelet aggregation activity. The synthesis of 1, related hydroxystilbenes, and their glucosides has been.

In vitro anti-platelet aggregation activity of the extracts of protorhus .

Platelet aggregation beyond purpose of haemostasis is the underlying cause of blood-clotting related diseases. Concoctions of P. longifolia are used by Zulu traditional healers to manage such diseases. This work aimed at investigating the anti-platelet aggregation activity of the extracts of this plant and to identify and.

The anti-platelet aggregation activity of Rapanea melanophloeos -A .

The anti-platelet aggregation activity of Rapanea melanophloeos -A. Zulu medicinal plant. By. Phiwamandla Emmanuel Gwala. 20055765. Submitted to the Faculty of Science and Agriculture, in partial fulfilment of the requirements for the degree of. Master of Science in the. Department of Biochemistry and Microbioogy.

In Vitro Antiplatelet Aggregation Activity of Centella . - Impact Factor

Apr 1, 2016 . ABSTRACT. The death on cardiovascular disease can be caused by thrombosis. Thrombosis is triggered by irreversible activity of thrombocyte aggregation. However, almost all prescribed drugs exhibiting antiplatelet activity are associated with a large number of side effects. Then, exploration of medicinal.

Synthesis, Antiplatelet Aggregation Activity Evaluation and 3D .

Feb 9, 2016 . Abstract. A series of novel 6-alkylamino(alkoxyl)-2-propylthio-8-azapurine nucleosides were synthesized by an improved route, and the human antiplatelet aggregation activities of these new compounds were evaluated. A self-organizing molecular field analysis method was used to study the.

Antiplatelet aggregation activity of 5-Hydroxyflavone, 2 .

Antiplatelet aggregation activity of 5-Hydroxyflavone, 2'-Hydroxyflavanone, Paeonol and bergenin isolated from stem bark of Garcinia malaccensis in human whole blood. Volume 29, Number 3. Khaled.A.A.Alkadi1, Aishah Adam1, Muhammad Taha2, Mizaton Hazizul Hasan2, Syed Adnan Ali Shah1,2*. 1Faculty of.

Construction and Characterization of Novel Staphylokinase Variants .

May 1, 2004 . Abstract. To develop target thrombolytic agents with fibrinolytic activity, antiplatelet aggregation activity and reduced immunogenicity, two staphylokinase variants containing Arg-Gly-Asp (RGD) motif were constructed. Gene expression was induced in E. coli JF1125 and the variants, designated DGR and.

aggregation activities antiplatelet,

Antiplatelet Aggregation Activity of Walnut Hull Extract via .

Mar 6, 2017 . Antiplatelet Aggregation Activity of Walnut. Hull Extract via Suppression of Reactive. Oxygen Species Generation and Caspase. Activation. Azadeh Meshkini*, Masoumeh Tahmasbi. Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad,. Mashhad, Iran. Available online 6 March.

Synthesis of Novel Indole Hydrazone Derivatives and Evaluation of .

Based on the existing reports regarding the antiplatelet aggregation activity of hydrazone derivatives, a series of indole hydrazone derivatives were considered as potential antiplatelet agents and synthesized. The structures of the synthesized compounds were confirmed by spectral data and elemental analysis. The new.

Platelet-Aggregation Inhibitory Activity of Oleanolic Acid, Ursolic .

aromaticum, respectively, were evaluated in vitro for anti-platelet aggregation activity on thrombin, adenosine diphosphate (ADP), and epinephrine-induced rat platelet aggregation. The triterpenes exhibited a dose dependent inhibitory activity on platelet aggregation induced by the three platelet agonists. The compounds.

Mechanisms Involved in the Antiplatelet Activity of Midazolam in .

Benzodiazepines exert many pharmacologic activities at the periphery. Among these activities, some benzodiazepines inhibit platelet aggregation. Triazolam and alprazolam inhibit platelet-activating factor–induced aggregation, 3 and the inhibition of platelet-activitating factor binding to platelets has been proposed to.

Antiplatelet and Anticoagulant Activities of Angelica . - SAGE Journals

activities against adenosine 50-diphosphate [ADP] and arachidonic acid-induced platelet aggregations) for the methanol extract of the aerial part (Angelica methanol extract [AME]), its isolated coumarins, flavonoids, and flavonoid metabolites. The AME had potent anticoagulant and antiplatelet activities, and the flavonoid.

Frontiers | Plant Alkaloids as Antiplatelet Agent: Drugs of the Future .

In terms of structure-activity relationship on these compounds' inhibition of platelet aggregation, it is assumed that the double bond in the C4–C9 position of the tricyclic aromatic structure confers a basal inhibition on collagen-induced platelet aggregation, as harmaline and harmalol showed the weakest antiplatelet activity,.

In vitro anti-platelet aggregation activity of the extracts of Camellia .

In vitro anti-platelet aggregation activity of the extracts of Camellia sinensis. Yadav Anu* and Mendhulkar V.D.. Department of Botany, Institute of Science, 15, Madam Cama Road, Fort, Mumbai,. Maharashtra- 400032. *Corresponding author Email: anudabur_18yahoo. Anti-platelet therapy is now appearing as an.

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